Research Abstracts Database

Animal Study

Andrographolide ameliorates vascular injury in hypertension by suppressing EndMT via Sp1-Notch1 signaling.

Sep 7, 2026 Tu Q, Li W, Qiu Y, Qiu Y, Liu Z, Zhang M, Liu Z, Xia W, Zhang B, Cao Z, Tao J

Phytomedicine : international journal of phytotherapy and phytopharmacology

Andrographolide

Hypertension

Vasoprotective

View abstract

Human Study

Vitamin D Deficiency Is Associated with Increased Depression Risk in Obese Asthma.

Sep 7, 2026 Liu M, Xiao J, Su J, Ou C, Lin Z, Liu J, Zhou M, Wu A, Liu H, Zhang Q, Zhang X

The journal of allergy and clinical immunology. In practice

Vitamin D

Asthma, Vitamin D Deficiency, Obesity, Depression

View abstract

Animal Study

The inhibition of deep peritoneal endometriosis by Andrographolide through macrophage M1 activity in an endometriosis mice model.

Sep 7, 2026 Susianto IA, Susilaningsih N, Hidayat ST, Hardian, Tjandrawinata RR, Rachmawati B

Veterinarni medicina

Andrographolide

Endometriosis

Anti-Inflammatory Agents, Immunomodulatory

View abstract

Animal Study

Andrographolide Attenuates Sepsis-Induced Acute Lung Injury via Peroxisome Proliferator-Activated Receptor Gamma in a Murine Cecal Ligation and Puncture Model.

Sep 7, 2026 Thimmana LV, Kalla HP, Ruhinaz KK, Byalla G, Panati K, Narala VR

Endocrine, metabolic & immune disorders drug targets

Andrographolide

Sepsis, Lung Damage

Antioxidants, Superoxide Dismutase Up-regulation, Catalase Up-Regulation

View abstract

In Vitro Study

Multi-target anti-hangover mechanisms of andrographolide and its analogs: a hypothesis-generating in silico, in vitro feasibility study.

Sep 7, 2026 Jadhav Y, Mukadam S, Bhingoli O, Unavane S, Kamble S, Naidu P, Girme A, Mali A, Shinde V

In silico pharmacology

Andrographolide

Hangover

View abstract

Animal Study

Andrographolide mitigates paraquat-induced pulmonary injury via PI3K/Akt/PPARγ pathway-mediated regulation of EMT and oxidative stress.

Sep 6, 2026 Zhang D, Zhao S, Xiao J, Cai Q, Zhao B

Pakistan journal of pharmaceutical sciences

Andrographolide

Pesticide Toxicity, Lung Damage

Antioxidants, Superoxide Dismutase Up-regulation, Catalase Up-Regulation, Paraquat

View abstract

Animal Study

Evaluation of autologous fecal microbiota transplantation for restoring equine gut microbiota after antibiotic-induced dysbiosis.

Sep 6, 2026 Kinoshita Y, Sato W, Ueno T

Journal of equine veterinary science

Dysbiosis, Antibiotic Toxicity

Gastrointestinal Agents, Microbiota Transfer Therapy

View abstract

Animal Study

Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice.

Sep 6, 2026 Luo X, Feng J, Sun Y, Tan Z, Wang L, Bao Y, Lu J, He J, Lu B

Frontiers in microbiology

Andrographolide

Colitis

Anti-Inflammatory Agents, Gastrointestinal Agents, NF-kappaB Inhibitor, Microbiota Transfer Therapy

View abstract

Animal Study

Andrographolide Alleviates Liver Damage Caused by Salmonella in Mice by Inhibiting the PANoptosis Pathway.

Sep 6, 2026 Li Q, Hou L, Su L, Wang X, Zhu Y, Fang B

Microorganisms

Andrographolide

Salmonella Infections, Liver Damage

Anti-Bacterial Agents, Hepatoprotective

View abstract

In Vitro Study

Synergistic anti-tumor activity of andrographolide and gemcitabine in intrahepatic cholangiocarcinoma through inhibition of RRM2 and the JAK/STAT3 pathway.

Sep 6, 2026 Song Q, Yu C, Sun F, Wang W, Wen Z, Chen R, Wang Y, Wang H, Wang Z, Li B, Yang L

Cancer chemotherapy and pharmacology

Andrographolide

Cholangiocarcinoma

Apoptotic, Antiproliferative, Chemosensitizer, Cell cycle arrest

View abstract

In Vitro Study

Andrographolide attenuates pulmonary fibrosis by covalently targeting Ptges3 and disrupting the Ptges3-Hsp90-NF-κB axis.

Sep 5, 2026 Zhang Q, Zhang Y, Wang C, Zhou L, Yang T, Zhu Q, Chu Z, Zhang J, Jiang M, Wang J, Pang H, Xu C, Tang H

Journal of advanced research

Andrographolide

Pulmonary Fibrosis

Anti-Inflammatory Agents, NF-kappaB Inhibitor, Anti-Fibrotic

View abstract

In Vitro Study

Synergistic effects of andrographolide and berbamine in glioblastoma: insights from proteomic and metabolomic pathway analysis.

Sep 5, 2026 Prakash V, Kalia M, Gabrani R

Bioorganic chemistry

Berbamine, Andrographolide

Glioblastoma

Apoptotic, Antiproliferative, Chemotherapeutic, Cell cycle arrest

View abstract

Animal Study

Evaluation of Andrographis paniculata in a mouse model of influenza A viral infection using oral administration and a translationally relevant dose.

Sep 5, 2026 Shamim K, Burnett GC, Zhang J, Ahmed NH, Khan SI, Chittiboyina AG, Khan IA, Marshall GD, Bates JT, Pugh ND

Frontiers in pharmacology

Andrographis

Influenza A

Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nrf2 activation

View abstract

In Vitro Study

Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma.

Sep 5, 2026 Yoshimura K, Shimura T, Ma R, Huang Y, Kitajima T, Yamashita S, Sato Y, Higashi K, Kawamura M, Yasuda H, Koike Y, Okita Y, Yoshiyama S, Kobayashi M, Ohi M, Ohge H, Takahashi S, Goel A, Okugawa Y, Toiyama Y

Oncology reports

Andrographis

Esophageal Cancer

Antiproliferative, Chemosensitizer

View abstract

Animal Study

Andrographolide Suppresses Influenza A Virus-Induced Pyroptosis via PI3K/AKT-Mediated Caspase-3/GSDME Inactivation.

Sep 5, 2026 Yang W, He Q, Sun Z, Zhang X, Li Q, Zhou C, Cui Y, Wei Z, Shi J, Wang C, Jiao Y, Guo L, Xing Y, Wang S

Biomedicines

Andrographolide

Influenza A

Anti-Inflammatory Agents

View abstract

Animal Study

Andrographolide attenuates neuroinflammation and apoptosis after spinal cord injury via PI3K-Akt pathway activation.

Sep 5, 2026 Li F, Zhao Q, Zhang J, Shen Z, Wang H

International immunopharmacology

Andrographolide

Spinal Cord Injuries

Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Interleukin-6 Downregulation, Interleukin-1 beta downregulation

View abstract

Animal Study

Andrographis paniculata Inhibits Tongue Squamous Cell Carcinoma via Regulating Wnt/β-Catenin Signaling and Epithelial-Mesenchymal Transition.

Sep 4, 2026 Yue GG, Huang J, Lu X, Lee JK, Gao S, Chan JYK, Lau CB

International journal of molecular sciences

Andrographis

Tongue Cancer

Angiogenesis Inhibitors, Apoptotic

View abstract

Animal Study

Andrographolide alleviates nasal mucosal inflammation in allergic rhinitis mice by inhibiting the IL-17/NF-κB pathway and downregulating MUC5AC expression.

Sep 4, 2026 Xi J, Liu X, Yue X, He Y, He Y, Fan X, Hao H, Li J, Li J, Wang Z, Chen D

Journal of ethnopharmacology

Andrographolide

Allergic Rhinitis

Anti-Inflammatory Agents, NF-kappaB Inhibitor, Interleukin-17 downregulation

View abstract

In Vitro Study

Low-dose Andrographolide Synergizes With Cytarabine or Vincristine in Plasma Cell Neoplasm Cell Lines.

Sep 4, 2026 Doi H, Akiyama H, Matsui T, Abe Y, Fujii S, Matsuura H, Miura Y

Anticancer research

Andrographolide

Multiple Myeloma

Apoptotic

View abstract

Animal Study

Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling.

Sep 4, 2026 Song H, Yang M, Wu S, Dai Q, Qin W, Xie W, Chen Y, Jiang X, Zhang X, Deng X, Ouyang C, Zhang Y, Liu X, Zhu Y, Huang G

iScience

Andrographolide

Alzheimer's Disease

Neuroprotective Agents

View abstract

Animal Study

Andrographolide Suppresses Head and Neck Squamous Cell Carcinoma Progression via EGR1-ACSL4 Axis-Mediated Ferroptosis.

Sep 4, 2026 Cheng G, Zhu X, Zhang C

The American journal of Chinese medicine

Andrographolide

Head and Neck Cancer

Antiproliferative

View abstract

Animal Study

Effect of cannabidiol, cannabinol and tetrahydrocannabivarin in managing inflammatory pain.

Sep 4, 2026 Poceviciute I, Simkunaite-Rizgeliene R, Mlost J, Buisas R, Ruksenas O, Starowicz K, Vengeliene V

Scientific reports

Cannabidiol, Cannabinoids

Inflammation

Analgesics

View abstract

Animal Study

Acteoside relieves diabetic retinopathy through the inhibition of Müller cell reactive hyperplasia by regulating TXNIP and mediating Kir4.1 channels in a PI3K/Akt-dependent manner.

Sep 3, 2026 Xi X, Liu X, Chen Q, Ma J, Wang X, Gui Y, Zhang Y, Li Y

PloS one

Verbascoside

Diabetic Retinopathy

View abstract

Animal Study

Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence.

Sep 2, 2026 Creangă-Murariu I, Rezuș II, Karami R, Makolli A, Chifu C, Rancz A, Sipos Z, Ferdinandy P, Papp R, Teutsch B, Tamba BI, Hegyi P, Bunduc S

Pharmaceuticals (Basel, Switzerland)

Cannabinoids

Glioblastoma, Breast Cancer

Antiproliferative, Chemotherapeutic

View abstract